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Beckmann reaction of oximes catalysed by chloral: mild and neutral procedures

Chandrasekhar, Sosale and Gopalaiah, Kovuru (2003) Beckmann reaction of oximes catalysed by chloral: mild and neutral procedures. In: Tetrahedron Letters, 44 (4). pp. 755-756.

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A variety of ketoximes undergo the Beckmann rearrangement when heated with 0.5 molar equiv. of chloral (neat melt/1\sim30°C), to furnish the corresponding amides in excellent yields (generally 80–95%) after simple work-up. (Aromatic aldoximes dehydrated to the corresponding nitriles in excellent yields under similar conditions.) The absence of solvent, Brønsted acids, strong Lewis acids and by-products, and a simple work-up characterise the procedures.

Item Type: Journal Article
Publication: Tetrahedron Letters
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Beckmann rearrangement;catalytic;chloral;environmentally mild
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 05 Dec 2008 06:07
Last Modified: 19 Sep 2010 04:52
URI: http://eprints.iisc.ac.in/id/eprint/16594

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