Antimycobacterial Activity and Mechanism of Action of $NAS-91^\nabla$

Gratraud, Paul and Surolia, Namita and Besra, Gurdyal S and Surolia, Avadhesha and Kremer, Laurent (2008) Antimycobacterial Activity and Mechanism of Action of $NAS-91^\nabla$. In: Antimicrobial Agents and Chemotherapy, 52 (3). pp. 1162-1166.

PDF 1162.pdf Restricted to Registered users only Download (587kB) | Request a copy

Abstract

The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for \Delta9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.

Item Type:	Journal Article
Publication:	Antimicrobial Agents and Chemotherapy
Publisher:	American Society for Microbiology
Additional Information:	copyright of this article belongs to American Society for Microbiology.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	26 Aug 2008
Last Modified:	19 Sep 2010 04:49
URI:	http://eprints.iisc.ac.in/id/eprint/15634

Actions (login required)

View Item