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Drugs and drug targets against malaria

Padmanaban, Govindarajan and Nagaraj, Arun V and Rangarajan, Pundi N (2007) Drugs and drug targets against malaria. In: Current Science, 92 (11). pp. 1545-1555.


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The development of resistance by the parasite against first line and second line antimalarial drugs, has underscored the importance to develop new drug targets and pharmacophores to treat the disease. The absence of a vaccine for protection and the availability of artemisinin and its derivatives as the only option has made the situation rather serious. With the availability of increased support for malaria research, a variety of drug targets and candidate molecules are now available for further development. However, the success rate of a candidate molecule to become a drug is very low and it does become necessary to start with a large basket, identified on a rational basis. This review focuses on the present efforts to identify a variety of drug targets in the malaria parasite and to develop candidate drug molecules.

Item Type: Journal Article
Publication: Current Science
Publisher: Indian Academy of Sciences
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: Artemisinin;drug molecules;drug targets;malaria parasite.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 05 Aug 2008
Last Modified: 19 Sep 2010 04:48
URI: http://eprints.iisc.ac.in/id/eprint/15427

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