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Effect of cupric-isonicotinic acid hydrazide complex on normal and avian myeloblastosis virus-infected cells cultivated in vitro

Vasudevachari, MB and Antony, A (1985) Effect of cupric-isonicotinic acid hydrazide complex on normal and avian myeloblastosis virus-infected cells cultivated in vitro. In: Journal of Biosciences, 7 (1). pp. 33-38.

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Abstract

The cupric complex of isonicotinic acid hydrazide was found to be nontoxic to normal yolk sac macrophages upto a concentration of 100 ΜM. At this concentration the complex did not significantly inhibit DNA, RNA or protein synthesis in these cells. The complex inhibited the avian myeloblastosis virus multiplication in these cells when added 0–4 h post-infection as demonstrated by the inhibition of both focus formation and expression of viral specific antigens. This inhibition was not observed when the complex was added 8 and 16 h after avian myeloblastosis virus infection. The studies carried out on avian myeloblastosis virus-transformed myeloblasts indicated that the complex had no effect on the colony (focus) formation. The results suggest that the complex inhibits the virus multiplication by interfering in an early event of viral growth cycle, possibly the process of reverse transcription.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Springer India
Keywords: Cupric complex of isonicotinic acid hydrazide;avian myeloblastosis virus;yolk sac macrophages;transformed myeloblasts'focus assay;viral specific antigens;colony formation.
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Depositing User: H.S. Divakara
Date Deposited: 10 Jul 2008
Last Modified: 27 Aug 2008 13:33
URI: http://eprints.iisc.ac.in/id/eprint/14897

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