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Conformation of polyene antibiotic, filipin III: CD and proton NMR studies

Balakrishnan, Rajini A and Easwaran, KRK (1993) Conformation of polyene antibiotic, filipin III: CD and proton NMR studies. In: Journal of Biomolecular Structure & Dynamics, 11 (2). pp. 417-428.

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Detailed studies on the solution conformation of polyene antibiotic, filipin III (I) using CD and proton NMR techniques have been carried out. In DMSO, filipin III exhibits concentration-dependent aggregation - monomeric at lower and oligomeric at higher concentrations of the antibiotic. At concentrations used for $^1H$ NMR studies $(6 \times 10^{-3} M)$ the molecular coexists as monomeric and oligomeric species. However, titration experiments indicated that, in a mixed solvent system of DMSO:methanol (2:3 vol./vol.) the antibiotic exists only as a monomer. Complete $^1H$ NMR assignments and the conformation of the monomer filipin III have been detected by the combined use of DQFCOSY and ROESY experiments in DMSO:methanol solvent system.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Adenine Press.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Depositing User: Mr. Ramesh Chander
Date Deposited: 01 Jul 2008
Last Modified: 27 Aug 2008 13:30
URI: http://eprints.iisc.ac.in/id/eprint/14624

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