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Synthesis of distamycin and netropsin analogs. Part II. DNA binding bisquaternary ammonium heterocycles analogs to NSC 101327

Rao, EK and Sasisekharan, V (1990) Synthesis of distamycin and netropsin analogs. Part II. DNA binding bisquaternary ammonium heterocycles analogs to NSC 101327. In: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 29 (6). pp. 503-507.

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Abstract

Synthesis of novel oligopeptides I and II related to the antileukemic agent NSC 101327 is described. These compds. are designed to understand the role of curvature of the ligands in sp. interactions of the drugs, distamycin and netropsin with nucleic acids. In contrast to a dicarboxylic acid starting material for the parent compds., the synthesis of new analogs employ m- or p-phenylenediamine. The new analogs contain nicotinyl end groups.

Item Type: Journal Article
Additional Information: The copyright belongs to National Institute of Science Communication and Information Resources. The latest full-text is available, back issues yet to be online.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Depositing User: CA Sharada
Date Deposited: 08 Feb 2008
Last Modified: 27 Aug 2008 13:07
URI: http://eprints.iisc.ac.in/id/eprint/12704

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