Padmanaban, G and Rangarajan, PN and Venkateswar, V and Rao, Venkateswara M and Upadhya, Poornima (1990) Transcriptional regulation of cytochrome P-450b/e gene expression in rat liver. In: Biological Oxidation system (Proceedings symposium), 1989.
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The regulatory features of the transcriptional activation of the cytochrome P-450IIB1/B2(b/e) genes in rat liver by phenobarbitone have been examd. Heme as a pos. modulator, and dexamethasone modulator of the action of the pos. activator were examd. The upstream sequence within -179 nucleotides of the cytochrome P-450b/e genes has been found to respond to the various regulatory features mentioned. Apparently, phenobarbitone induces a set of transcription factors leading to the transcriptional activation of the P-450b/e genes in rat liver. Conditions resulting in an interference with the-drug mediated increase in transcription are invariably assocd. with a decrease in the interaction of 90Kd proteins with an upstream sequence. The cytochrome P-450b/e genes also manifest elongation regulation at the level of transcription.
| Item Type: | Conference Proceedings |
|---|---|
| Publisher: | Academic |
| Additional Information: | Copyright of this article belongs to Academic. |
| Keywords: | Transcriptional regulation;cytochrome;rat liver;phenobarbitone |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 27 Dec 2007 |
| Last Modified: | 05 Nov 2018 09:39 |
| URI: | http://eprints.iisc.ac.in/id/eprint/12584 |
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