Crystal structure of putrescine aspartic acid complex

Ramaswamy, S and Murthy, MRN (1990) Crystal structure of putrescine aspartic acid complex. In: Current Science, 59 (7). pp. 379-382.

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Abstract

Polyamines, putrescine, spermidine and spermine are ubiquitous biogenic cations believed to be important for a variety of cellular processes. In order to obtain structural information on the interaction of these amines with other biomolecules, the structure of a complex of putrescine with aspartic acid was determined using single crystal X-ray diffraction methods. The crystals belong monoclinic space group $C_2$ with $a = 21.504 \AA$, $b = 4.779 \AA$, $c = 8.350 \AA$ and $\beta = {97.63}^{\circ}$. The structure was refined to an R factor of 8.4% for 664 reflections. The asymmetric unit contains one aspartic acid and half putrescine molecule. The conformation of aspartic acid corresponds to its most favorable extended structure. The putrescine molecule, although on a 2-fold special position, lacks 2-fold symmetry. The putrescine backbone has a transgauche conformation. The energy required for distorting the putrescine molecule from its most favourable zigzag structure is presumably derived from both hydrogen bonding and electrostatic interactions.

Item Type:	Journal Article
Publication:	Current Science
Publisher:	Indian Academy of Sciences
Additional Information:	Copyright of this article belongs to Indian Academy of Sciences.
Keywords:	x-ray crystallog;putrescine mol;putrescine backbone;Crystal structure
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	08 Nov 2007
Last Modified:	19 Sep 2010 04:41
URI:	http://eprints.iisc.ac.in/id/eprint/12446

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