Biocatalyst-mediated expansion of ring D in azadirachtin, a potent insect antifeedant from Azadirachta indica

Madyastha, KM and Venkatakrishnan, K (1999) Biocatalyst-mediated expansion of ring D in azadirachtin, a potent insect antifeedant from Azadirachta indica. In: Tetrahedron Letters, 40 (28). pp. 5243-5246.

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Abstract

A microorganism identified as Nocardia Sp.capable of converting azadirachtin 1 into three metabolites, viz. 3-deacetylazadirachtin 2, 1-detigloyl-3-deacetyl-azadirachtin-1-ene-3-one 3 and 1-detigloyl-3-deacetyl-11,19-deoxa-12,19-oxa-11-oxo-azadirachtin-1-ene-3-one 4, has been isolated. This is the first report on the functionalization of azadirachtin using biocatalysts wherein two novel, hitherto unknown metabolites have been isolated and characterized.

Item Type:	Journal Article
Publication:	Tetrahedron Letters
Publisher:	Elsevier
Additional Information:	Copyright of this article belongs to Elsevier.
Keywords:	Azadirachta indica;Azadirachtin;Biocatalyst;Nocardia Sp.;α,β-unsaturated ketone;α-keto-δ-lactone
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	15 Oct 2007
Last Modified:	19 Sep 2010 04:40
URI:	http://eprints.iisc.ac.in/id/eprint/12094

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