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Non-protein amino acids in peptide design

Aravinda, S and Shamala, N and Roy, Rituparna S and Balaram, P (2003) Non-protein amino acids in peptide design. In: Journal of Chemical Sciences, 115 (5 & 6). pp. 373-400.


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An overview of the use of non-protein amino acids in the design of conformationally well-defined peptides, based on work from the author’s laboratory, is discussed. The crystal structures of several designed oligopeptides illustrate the use alpha-aminoisobutyric acid (Aib) in the construction of helices, D-amino acids in the design of helix termination segments and DPro–Xxx segments for nucleating of beta-hairpin structures. beta- and gamma-amino acid residues have been used to expand the range of designed polypeptide structures.

Item Type: Journal Article
Publication: Journal of Chemical Sciences
Publisher: Indian Academy of Sciences
Additional Information: Journal of Chemical Sciences previously named as Proceedings of Indian Academy of Sciences (Chemical Sciences)
Keywords: Peptide design;Crystal structures;C–HLO hydrogen bond;Hybrid peptides;D-amino acids;beta-amino acids
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Division of Physical & Mathematical Sciences > Physics
Date Deposited: 30 Jul 2004
Last Modified: 19 Sep 2010 04:14
URI: http://eprints.iisc.ac.in/id/eprint/1206

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