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Small-world network topology of hippocampal neuronal network is lost, in an in vitro glutamate injury model of epilepsy

Srinivas, Kalyan V and Jain, Rishabh and Saurav, Subit and Sikdar, Sujit K (2007) Small-world network topology of hippocampal neuronal network is lost, in an in vitro glutamate injury model of epilepsy. In: European Journal of Neuroscience, 25 (11). pp. 3276-3286.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1460-...


Neuronal network topologies and connectivity patterns were explored in control and glutamate-injured hippocampal neuronal networks, cultured on planar multielectrode arrays. Spontaneous activity was characterized by brief episodes of synchronous firing at many sites in the array (network bursts). During such assembly activity, maximum numbers of neurons are known to interact in the network. After brief glutamate exposure followed by recovery, neuronal networks became hypersynchronous and fired network bursts at higher frequency. Connectivity maps were constructed to understand how neurons communicate during a network burst. These maps were obtained by analysing the spike trains using cross-covariance analysis and graph theory methods. Analysis of degree distribution, which is a measure of direct connections between electrodes in a neuronal network, showed exponential and Gaussian distributions in control and glutamate-injured networks, respectively. Although both the networks showed random features, small-world properties in these networks were different. These results suggest that functional two-dimensional neuronal networks in vitro are not scale-free. After brief exposure to glutamate, normal hippocampal neuronal networks became hyperexcitable and fired a larger number of network bursts with altered network topology. The small-world network property was lost and this was accompanied by a change from an exponential to a Gaussian network.

Item Type: Journal Article
Publication: European Journal of Neuroscience
Publisher: John Wiley and Sons
Additional Information: Copyright of this article belongs to John Wiley and Sons.
Keywords: cross-covariance analysis;hippocampal neurons;multielectrode array;network bursts
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 12 Oct 2007
Last Modified: 03 Feb 2012 06:19
URI: http://eprints.iisc.ac.in/id/eprint/11790

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