Nuclear Magnetic Resonance Studies of the Enzymatic Hydrolysis of Acetylcholine: A Critical Comment

Krishnan, KS and Balaram, P (1977) Nuclear Magnetic Resonance Studies of the Enzymatic Hydrolysis of Acetylcholine: A Critical Comment. In: Molecular Pharmacology, 13 (4). pp. 621-624.

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Abstract

Studies at 100 MHz of the hydrolysis of acetylcholine by brain membrane-bound acetylcholinesterase show that the N-methyl resonance acquires a doublet character as the hydrolysis proceeds. These results provide a simple explanation for the time-dependent NMR line broadening observed earlier for the interaction of acetylcholine with purified acetylcholinesterase.

Item Type:	Journal Article
Publication:	Molecular Pharmacology
Publisher:	Academic Press
Additional Information:	Copyright for this article belongs to Academic Press.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	26 Jul 2004
Last Modified:	19 Sep 2010 04:14
URI:	http://eprints.iisc.ac.in/id/eprint/1162

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