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Regulation of DNA topology in mycobacteria

Nagaraja, V (2004) Regulation of DNA topology in mycobacteria. In: Current Science, 86 (1). pp. 135-140.


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DNA topoisomerases catalyse essential DNA transaction processes in order to attain the balanced topology of the genome. Contrasting activities of DNA topoisomerase I and DNA gyrase result in the maintenance of topological homeostasis. The regulation of expression of different topoisomerases ensure steady state optimum level expression of the enzymes. Many aspects of their organization and regulation seem to be different in mycobacteria when compared with that of Escherichia coli. Here we present several aspects of the regulation of mycobacterial topoisomerases and discuss the significance.

Item Type: Journal Article
Publication: Current Science
Publisher: Indian Academy of Science
Keywords: DNA topology;mycobacteria
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 22 Jul 2004
Last Modified: 19 Sep 2010 04:14
URI: http://eprints.iisc.ac.in/id/eprint/1126

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